After the Spanish conquest, Catholic missionaries campaigned against the cultural tradition of the Aztecs, dismissing the Aztecs as idolaters, and the use of hallucinogenic plants and mushrooms, like other pre-Christian traditions, were quickly suppressed.
The Spanish believed the mushroom allowed the Aztecs and others to communicate with devils.
Inspired by the Wassons' Life article, Timothy Leary traveled to Mexico to experience psilocybin mushrooms firsthand.
Upon returning to Harvard in 1960, he and Richard Alpert started the Harvard Psilocybin Project, promoting psychological and religious study of psilocybin and other psychedelic drugs.
The first 3–4 hours of the trip are typically referred to as the 'peak' in which the user experiences more vivid visuals, and distortions in reality.